ZNF217 is a zinc finger protein implicated in gene regulation with seven predicted classical ZFs, it has also been identified as a candidate oncoprotein associated with breast cancer’s prognosis under high levels of density. This model aims to emphasize the unique property of the sixth and seventh ZFs to bind double-stranded DNA, which makes several base-specific contacts with DNA not typical in classical ZF-DNA complexes. There is a guanidinium group of Arg-481, and an aromatic ring of Tyr-516 in the F6 and F7 in ZNF217 forming two methyl-π interactions. Electrostatic interactions were made by the side chains of Tyr-484, Tyr-485, and Thr-492. With the sugar-phosphate backbone. The F7’s sequence-specific interactions with DNA is stabilized by Gln-510, Tyr-516, Thr-512, and Tyr-506.
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