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More model informationZinc finger proteins are the largest family of DNA-binding transcription regulators in mammals, meaning they are involved in regulating the amount of mRNA that is transcribed from DNA. This affects the protein expression from that particular sequence. The model shows ZFP568, a zinc finger protein in mice, and the section of DNA it binds to regulate transcription. The DNA sequence shown is upstream of the placental-specific insulin like growth factor 2 (Igf2-P0) promoter. ZFP568 directly binds to this sequence, ultimately repressing the Igf2-P0 transcript (i.e. reducing the transcription of the gene into mRNA) in early mouse development.
Mar 22nd 2024
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