Triosephosphate isomerase (TPI) is a key enzyme in the glycolytic pathway it catalyzes the conversion of the sugar phosphates dihydroxyacetone phosphate (DHAP) into glyceraldehyde 3- phosphate (G3P). This reaction is crucial for the production of ATP. This model shows the Malaria (Plasmodium falciparum) Triosephosphate isomerase. The malaria TPI is highly conserved across different strains of the parasite, but in comparison with the human TPI, it shows structural features that differentiate it. The surface residue Leu183, the residue Cys13 and the residue Phe96 close to the active site. These differences make it an attractive target for the development of new antimalarial drugs that do not affect the human TPI. The enzyme can be found in an open and closed state, this model is showing the closed wild-type state.
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