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More model informationRAP1 is a sequence specific DNA binding protein found in Yeast cells. RAP1 binds strongly to DNA sites containing the sequence 5’-(A/G)(C/A)A(C/T)CC(A/G)(C/A)NCA(C/T)(C/T)-3’ which can be found at the end of telomeres or RAP1-binding sites in the promoter region of a vast number of genes. Its functions include tellomere length regulation, and the activation and repression of transcription. RAP1 is made up of three key structures N-terminal domain, C-terminal domain and the C-terminal tail. All three structures interact with DNA, positioning themselves in the major groove of the specific DNA binding sequence.
Reference DOI: 10.1016/s0092-8674(00)81088-0
Mar 27th 2020
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