The continued outbreak of the COVID-19 pandemic has allowed scientists to re-launch research on the coronavirus and expected to develop more effective antiviral drugs. The viral papain-like cysteine protease (PLpro, NSP3) is a protease that can affect virus replication and inhibit the host immune response. It involved activating the immune system and actively attacking cell signalling pathways by encoding proteins. Because of this feature, it has become a key research object of researchers. This Sketchfab model shows how SARS-CoV-2 PLpro immediately reacts with the VIR250 inhibitor and shows the role of each protein in its process.
Reference: Rut, W., Lv, Z., Zmudzinski, M., Patchett, S., Nayak, D., Snipas, S.J., … Olsen, S.K. (2020). Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Science Advances, 6(42). DOI:10.1126/sciadv.abd4596
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