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More model informationA homeodomain (HD) is an evolutionarily conserved protein which recognises and binds to specific DNA sequences. The NKX2.5 protein is a homeodomain which contains a transcription factor regulating cardiac formation and function, with mutations of it being heavily linked to congenital heart disease. Here, we explore the three regions of the HD which consist of the residues that interact with, and bind to DNA.
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Mar 18th 2023
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