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More model informationThe Maf transcription factor regulates gene expression and cell specialization. This placed significance on the study of diseases associated with the structure.
The Maf transcription factor contains a leucine zipper region and a basic (DNA binding) region. The bZip proteins usually recognize specific DNA motifs. Specific to this Maf model, it recognizes a 13bp MARE (specifically T-MARE) region on the DNA. This model aims to describe essential components that are vital to the functioning of this transcription factor.
These components include:
- The DNA code specific to Maf (MARE).
- The leucine-zipper region.
- The basic region.
- The two very conserved amino acid residue.
The importance of these components include:
- DNA binding.
- Specificity to a defined DNA region.
- Dimerization necessary for its molecular functioning.
PDB ID: 3A5T
Doi:10.1128/MCB.00708-09
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