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More model informationHIV-1 protease is an enzyme that cleaves viral proteins and is needed for the lifecycle of HIV. It is a dimer where the active site is found between the subunits, treatments target HIV-1 protease by using Saquinavir (SQV). Saquinavir is a protease inhibitor containing mainchain amides and carbonyl oxygen atoms. Saquinavir competitively binds to the active site of the HIV-1 protease and prevents cleavage of viral polyproteins, preventing maturation of the virus
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