Triangles: 72.2k
Vertices: 40.7k
More model informationTriosephosphate isomerase (TPI or TIM) is a remarkably efficient enzyme, infamous for its diffusion-limited rate of reaction.
Come explore an overview of some key structural features leading to the role of the human TPI enzyme as an essential biochemical catalyst during step 5 of glycolysis! Moreover, this will highlight the importance of the ‘enzymatic dogma’ denoting the intrinsic link between structure and function, as well as why enzymopathies such as TPI deficiency may arise when mutations occur.
(NB: this discusses the conversion of DHAP to G3P, however the model used has 2-PG (a transition state analogue) bound at the active site, due to its enabling of a more stable complex during crystallography).
Lena Clarke
Comments