FosB/JunD bZIP heterodimer is an AP-1 complex found predorminantly in the brain (Yin et al. 2017). It binds to the AP-1 site in DNA and regulates gene expression, although a large conformational change is needed for FosB bZIP in order to bind to DNA due to its structure while it is free floating, which involved a kink at R175-R176-R177, causing the motif that is supposed to bind to the AP-1 site to be away from it (Yin et al. 2017). The binding and conformational change is controlled by “redox switch”- consist of disulfide bond between FosB and JunD at C172 and C285 repectively, where the bond is broken under reduced condition (Yin et al. 2017). JunD also protects cells from oxidants and seizures induced by a splice variant of FosB/ JunD (Yin et al. 2017). Yin, Z, Machius, M, Nestler, EJ, & Rudenko, G 2017, ‘Activator Protein-1: redox switch controlling structure and DNA-binding’, Nucleic Acids Research, vol. 45, no. 19, pp. 11425-11436
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