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More model informationJMJD2A, a member of the JmjC histone demethylase (HDM) family, stands out for its specialization in selectively demethylating methylated lysines via hydroxylation of ζ-methyl groups, particularly targeting H3K9me3 and H3K36me3 peptides. While its capability extends to binding various substrates along the histone H3 peptide backbone, JMJD2A’s primary focus centers on demethylating di- and trimethylated Lys9 and Lys36 residues. As this presentation zooms in on JMJD2A’s catalytic domain, especially when complexed with H3K9me3, we will look the features of the main chain, the key interactions in the active site, and explore the consequence of the mutation S288A.
Reference : DOI 10.1038/nsmb1273
Mar 29th 2024
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