Cone snails have been observed to incapacitate thier prey by injecting a slurry of slurry of short-chain bioacive peptides. This model will focus the cyclic peptide α-Conotoxin ImI of Conus imperalis, anatagonistically in complex with a LBD of Aplysia Califonica AcBP, a protein essential for its nerounal signal transmission. What has futher been discovered is selectivity of this toxin towards some human neuronal receptors (nAChR’s α7 (brain), α3β2 (cerebellum and spinal cord)). Scientists now consider Ac-AChBP to be a homolog model for some nAChR’s. After the discovery of Prialt (Conus Magnus), research has strenghened into conotoxin mechanisms. Understanding the biological interactions in full, may reveal a gateway into drug relief for certain neurological conidtions such as, Alzheimer’s, schizophrenia & addiction, which have pharmacological targets relevant to this current modelling. (https://tinyurl.com/2p9kjwdb, https://tinyurl.com/437u8w93, https://tinyurl.com/2aarsxu2, https://tinyurl.com/2x74hd2k)
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