Come explore this molecular theme park! Inspired by the toxic cone snail, this “interactive!” theme park will leave you paralyzed! with joy. Significant attractions you MUST see are labeled to show how they bond with the park’s natural environment and prevent the park from making connections and bonding with a competitor. Talk about a toxic relationship!
*This ACH receptor homolog molecule (AChBP) used in the experiments of Ulens et al. has significant binding with alpha-conotoxin as described in the above model.
Citations: Jeffrey, George A. An introduction to hydrogen bonding, Oxford University Press, 1997.
Ulens, Chris, et al. “Structural Determinants of Selective α-Conotoxin Binding to a Nicotinic Acetylcholine Receptor Homolog AChBP.” PNAS, vol. 103, no. 10, 27 Feb. 2006, pp. 3615–3620, https://doi.org/10.1073/pnas.0507889103.
Whitehouse, P.J. “Nicotinic Receptors.” Encyclopedia of Neurological Sciences, no. 2, 1 Jan. 2014, pp. 587–589, https://doi.org/10.1016/b978-0-12-385157-4.00070-1.
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