3.1C is a cyclic peptide; a polypeptide chain with a circular series of bonds. These are highly specific to certain targets and can rapidly be found via library technologies, making them useful research tools. Bromodomain and extraterminal domain (BET) proteins are a family in the bromodomain class implicated in many cancer types, as they can cause transcriptional deregulation, a key cancer hallmark. BET proteins have structurally very similar binding regions, called bromodomains (BDs), although they regulate different sets of genes and thus must be highly specific to their ligands. 3.1C was found to have a very high affinity for BRD3-BD1, a BD on the BET protein BRD3, and thus could inhibit it, preventing its oncogenic effects. Through the lens of the show ‘Breaking Bad’, this model takes you on a tour of the interaction between the BRD3-BD1 and 3.1C.
Sources: https://tinyurl.com/axzrsb4s, https://tinyurl.com/4fnc2uvb, https://tinyurl.com/25u7hjpm, https://tinyurl.com/2ur2afa6,
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