Here we explore the a-conotoxin ImI cyclic peptide, we get to see the cyclic structure and interactions between a-conotoxin ImI and Ac-AChBP and nAChR. This cyclic peptide is from the venom of cone snail Conus imperialis. In this model we can see 5 key interactions like salt bridges between ARG-11 and GLU-191, ARG-7 and ASP-5. Hydrogen bonds between ARG-7: TYR-91, TRP-145, ILE-194 and complementary hydrogens bonds between GLN-55, CYS-3, SER-4, SER-164 and ASP-162. CYS Disulfide bridges between CYS-2 and CYS-8 , CYS-188 and CYS-189. The interactions help ImI to bind to Ac-AChBP and recognizing nAChR subtypes. This peptide may be a future drug to help inhibit the growth of lung cancer cells. This could be an evolutionary anti-cancer drug with future advancements.
References: Ulens, Chris, et al. “Structural Determinants of Selective Alpha-Conotoxin Binding to a Nicotinic Acetylcholine Receptor Homolog Achbp.”7 Mar. 2006, www.ncbi.nlm.nih.gov/pmc/articles/PMC1450132/.
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