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More model informationThe human centromere protein B (CENP-B), one is an 80 kDa protein that contains a DNA-binding region at the N-terminus. We dtermined the crystal sturcture of the DNA-binding region of CENP-B comlpexed with a 21 bp CENP-B box DNA at 2.5 Å resolution. This is the first structure of a centromere-specific protein-DNA complex. And the CENP-B box has three important sites, 1, 2 and 3 for recognizing CENP-B protein, and those binding sites in CENP-B protein are located in N-terminal arm, domain 1, the linker loop and domain 2. And also, domain 1 and 2 gives kink-straight-kink bend in two protein contact site in DNA regions.
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